Pathophysiology Module 1-28.pdf - 1.5 Tissue Organization Pathophysiology Correll Hyperplasia is an increase in the size of an organ or tissue caused by

Pathophysiology Module 1-28.pdf - 1.5 Tissue Organization...

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6/9/2020 1.5: Tissue Organization: Pathophysiology- Correll 4/8 Hyperplasia is an increase in the size of an organ or tissue caused by an increase in the number of cells making up that organ or tissue. An example of this is glandular proliferation in the breast tissue during pregnancy. In some cases, hyperplasia can occur in conjunction with hypertrophy. During pregnancy, uterine enlargement is caused by both hypertrophy and hyperplasia of the smooth muscle cells in the uterus. Notably, pathologic hyperplasia can progress to dysplasia (see below) and eventually cancer. Metaplasia is the replacement of one differentiated tissue by another. Metaplasia usually occurs in response to chronic irritation and inflammation. This transformation of cells allows for a higher likelihood of survival in a less than optimal environment. Barrett esophagus is a classic example of this. In people with chronic gastroesophageal reflux disease (GERD), the normal
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  • Fall '17
  • 202
  • Gastroesophageal reflux disease, esophageal cancer, Cervical intraepithelial neoplasia, Metaplasia, Barrett's esophagus

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