Lect7-BacteriaMappingMOD

Lect7-BacteriaMappingMOD - Example 1) Ly 2) + + 3) Ly 4) +...

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Example 1) Ly Sb br 404 2) + + + 422 3) Ly + + 18 4) + Sb br 16 5) Ly + br 75 6) + Sb + 59 7) Ly Sb + 4 8) + + br 2 Total = 1000
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Inaccuracies in Mapping Larger the distance = more inaccurate Since some DCOs will not be detected Interference: crossover events inhibits another
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Interference Interference = 1 –C C = coefficient of coincidence which is ratio of Observed DCO to Expected DCO Can be Positive, complete or negative
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Lecture outline Linked v. Independently Assorted genes Three meiotic consequences Linkage ratio Distance between linked genes Gene sequence determination Inaccuracies in Mapping Mapping of human chromosomes
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Tools to map human chromosomes LOD score pedigree + probability Somatic cell hybrids (human + mouse) Heterokaryon Synkarion loss of chromosomes
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Genetic Analysis and Mapping in Bacteria and Bacteriophages
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Lecture outline Conjugation Transformation Bacteriophage characteristics Transduction Mapping in bacteriophages
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Conjugation Lederberg and Tatum experiment Fertility Factor and Hfr strains Chromosome mapping Recombination proteins
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onclusion: ransfer of genetic material occurs
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This note was uploaded on 09/23/2011 for the course BIOLOGY 283 taught by Professor Pedro during the Spring '11 term at UC Irvine.

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Lect7-BacteriaMappingMOD - Example 1) Ly 2) + + 3) Ly 4) +...

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