Lect8-DNAStructure

Lect8-DNAStructure - RH double helix Chains are...

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Plaque assay
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DNA Structure
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Transmissio n Molecular Populatio n Genetics
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Lecture outline How DNA was discovered to be genetic  material DNA Structure
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Four characteristics of genetic  material Replication Information storage Information expression Variation by mutation
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The Central Dogma DNA   RNA   Protein
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Lecture outline How DNA was discovered to be genetic  material Griffith’s, Avery/MacLeod/McCarty,  Hershey/Chase DNA Structure
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Griffith’s Experiment
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Rough and Smooth  S.  pneumoniae
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Conclusion: Heat-killed IIIS bacteria converted IIR - Called it Transformation
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Avery, MacLeod and McCarty’s  Experiment Modified Griffith’s experiment Used filtrate and plated cells on media
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Hershey-Chase Experiment
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Lecture outline How DNA was discovered to be genetic  material DNA Structure
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Watson-Crick Model
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Unformatted text preview: RH double helix Chains are antiparallel (Orientation of C5-C3 in opposite directions) Bases are stacked with separation of 3.4 Hydrogen bonds pair bases Complete turn is ten bases - 34 Major and minor grooves 20 in diameter RH double helix Bases are stacked with separation of 3.4 Complete turn is ten bases - 34 Major and minor grooves 20 in diameter Chains are antiparallel (Orientation of C5-C3 in opposite directions) Bases are stacked with separation of 3.4 Hydrogen bonds pair bases Alternative forms of DNA B-DNA: Normal aqueous state A-DNA: Dehydrated state Z-DNA: GC bases (LH helix)...
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Lect8-DNAStructure - RH double helix Chains are...

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