Lect13-GeneMutationDNARepair

Lect13-GeneMutationDNARepair - GeneMutationandDNA repair...

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Gene Mutation and DNA  repair
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Outline How mutations are classified Spontaneous and Induced Mutations Mechanisms of DNA repair DNA synthesis DNA Damage Testing for Mutagenicity Transposons
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Outline How mutations are classified Spontaneous and Induced Mutations Mechanisms of DNA repair DNA synthesis DNA Damage Testing for Mutagenicity Transposons
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Mutations Alterations in a DNA sequence From single nucleotide change to major  alterations Can occur within coding and non-coding  regions Can occur in somatic (non-heritable) or  germ cells (heritable) Divided into spontaneous (cause  unknown) and induced (caused by  extraneous factors)
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Classification based on Location Somatic Not  Transmitted Recessive not  seen in  diploids Germ-line Transmitted May be unnoticed  for generations Autosom al X-linked
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Classification based on Type Point mutation Missense Nonsense Silent Frameshift mutation Change in triplet reading Transition Pyrimidine to Pyrimidine Purine to Purine Transversion Pyrimidine to Purine
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Classification based on Phenotypic  Effect Loss of  function Reduces or  eliminates function Complete loss:  Null Dominant/Recessi ve Gain of  function Enhanced/new  function Usually  dominant Visible Nutritional Biochemical Behavioral Regulatory Conditional Temperature- sensitive Neutral
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Outline How mutations are classified Spontaneous and Induced Mutations Mechanisms of DNA repair DNA synthesis DNA Damage Testing for Mutagenicity Transposons
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Lect13-GeneMutationDNARepair - GeneMutationandDNA repair...

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