Lect18-CellCycle_CancerI

Lect18-CellCycle_CancerI - Cell Cycle Regulation and Cancer...

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Cell Cycle Regulation and Cancer
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Outline What is Cancer? Cancer Cell Characteristics Genomic Instability
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Cancer and aging Cancer incidence increases with age Suggest multiple rate limiting steps Many math models developed Overall cancer rates UK, 2002 info.cancerresearchuk.org Male rates Female rates
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What is Cancer? Up to 100 complex diseases. Share: abnormal cell growth and abnormal cell-cell interaction (leads to metastasis) Benign v. Malignant It is a genetic disease. A multistep process, requiring multiple mutations
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Characteristics of Cancer Cells Clonal in origin Acquired defects in various cell functions Display Genomic Instability
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Cancer cells exhibit…
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Outline What is Cancer? Cancer Cell Characteristics Genomic Instability
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Gary Larson, The Far Side ‘Rex’ the genome
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What is genomic instability? Genomic instability is a cellular phenotype characterized by an elevated mutation rate which results in an accumulation of mutations.
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Genome Stability in normal cells Genome (6 billion bp) must be duplicated and partitioned correctly each time the cell divides Genomes are not inert; continuous DNA damage occurs Factor that interact with cellular DNA during replication, repair and segregation are essential for maintaining a stable genome
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Fidelity of DNA replication/repair DNA Polymerases and their intrinsic exonuclease proofreading activity yield an error
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This note was uploaded on 09/23/2011 for the course BIOLOGY 283 taught by Professor Pedro during the Spring '11 term at UC Irvine.

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Lect18-CellCycle_CancerI - Cell Cycle Regulation and Cancer...

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