Lect19-CellCycle_CancerII

Lect19-CellCycle_CancerII - Cell Cycle Regulation and...

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Cell Cycle Regulation and Cancer II
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Outline Cell cycle and its checkpoints Proto-oncogenes Tumor suppressors Apoptosis Metastasis Other Cancer promoting factors
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The cell cycle Stimulated by signal transduction pathways Highly regulated by Cyclins and Cyclin dependent kinases (CDKs) POSITIVE regulation
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How does receptor activation start the cell cycle?
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Cyclins combine with CDKs Cyclin Cell cycle proteins P Inactive Cyclin dependent Kinase (CDK) Active Cyclin Cyclin dependent Kinase (CDK)
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Cell cycle checkpoints Points during cell cycle when cell monitors external signals and internal status Three checkpoints: G1/S, G2/M, M G1/S monitors cell size and DNA damage G2/M monitors DNA replication/repair M monitors formation of spindle fibers and attachment to kinetochores NEGATIVE regulation
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cycle Positive regulators promote growth/cell cycle progression Negative regulators inhibit growth/cell
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This note was uploaded on 09/23/2011 for the course BIOLOGY 283 taught by Professor Pedro during the Spring '11 term at UC Irvine.

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Lect19-CellCycle_CancerII - Cell Cycle Regulation and...

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