MetabolismNotes

MetabolismNotes - Chem 333 Metabolism Lecture Notes Michael...

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Unformatted text preview: Chem 333 Metabolism Lecture Notes Michael Palmer Department of Chemistry University of Waterloo Waterloo, Ontario, Canada 2 UNIVERSITY OF WATERLOO VISUAL IDENTITY GUIDE 2008 | The University of Waterloo logo consists of type and the shield. It features the University shield stylized from our armorial bearings and the name of the university above. The shield of the University of Waterloo has been used for over 50 years. It is very well recognized, and is our mark under Canadian law. The logo is to be used on all University materials. When the logo is used, its shape should not be altered in any way. The logo should not appear with any other mark, symbol, graphic, logo or logotype other than the approved wordmarks presented here. The Logo The University of Waterloo logo is available for download Preface These notes are for use with my 3 rd year undergraduate class on metabolism. The focus is on human metabolism, and more specifically on human energy me- tabolism. Apart from the pathways and reactions, several aspects of hormonal regulation and some medical correlations are also included. The entire text has been prepared by myself. The same applies to most figures; exceptions are indicated. With respect to my own material, you are welcome to use it in your own not-for-profit teaching materials as you see fit, provided that proper credit is given. These notes are currently in their 4 th edition. In this edition, some errors have been corrected, yet likely some more remain to be discovered, and new ones may have been introduced. I therefore welcome corrections and sug- gestions for improvement, no matter whether youre a colleague, a student, or simply an interested reader. Please send email to mpalmer@uwaterloo.ca. Thank you. Contents Chapter 1 Introduction 1 1.1 Motivation: Why would you study metabolism? . . . . . . . . . . 1 1.2 Catabolic and anabolic reactions . . . . . . . . . . . . . . . . . . . 1 1.3 Metabolic diversity . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.4 Types of foodstuffs . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.5 The digestive tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.6 Whats next? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Chapter 2 Refresher 16 2.1 How enzymes work: Active sites and catalytic mechanisms . . 16 2.2 Classification of Enzymes and enzyme reactions . . . . . . . . . 18 2.3 Energetics of enzyme-catalyzed reactions . . . . . . . . . . . . . 19 2.4 The role of ATP in enzyme-catalyzed reactions . . . . . . . . . . 21 2.5 Regulation of enzyme activity . . . . . . . . . . . . . . . . . . . . 23 Chapter 3 Glycolysis 26 3.1 Overview of glucose metabolism . . . . . . . . . . . . . . . . . . . 26 3.2 The place of glycolysis in glucose degradation . . . . . . . . . . 27 3.3 Reactions in glycolysis . . . . . . . . . . . . . . . . . . . . . . . . . 28 3.4 Mechanisms of enzyme catalysis in glycolysis . . . . . . . . . . 28 3.5 Energy-rich functional groups in substrates of glycolysis...
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This note was uploaded on 09/22/2011 for the course CHEM 333 taught by Professor Michaelpalmer during the Winter '07 term at Waterloo.

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MetabolismNotes - Chem 333 Metabolism Lecture Notes Michael...

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