Outline - Chapter 3

Outline - Chapter 3 - C hapter 3 P roteins P rotein...

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Chapter 3 Proteins Protein structure (pages 125- 148; figures 3-1 to 3-28, 3-35) 1. The Shape and structure of proteins - primary, secondary, tertiary, quaternary structure of proteins - primary structure – sequence of amino acids; peptide bond - secondary structures – α -helix and β -sheet; hydrogen bonds - tertiary structure – noncovalent bonds; folding of proteins into a conformation of lowest energy - quaternary structure – noncovalent bonds 2. Protein domain arrangements (module) - “In-line” – e.g. fibronectin type I, immunoglobulin - “plug-in” – e.g. SH2 domain, kringle 3. Proteins can be classified into many families 4. Sequence searches can identify close relatives - Generally a 30% identity suggests relatedness 5. Domain shuffling
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6. Quaternary structure of proteins - Weak bonds - “head to head” arrangement – dimmers - Single binding site - “head to tail” arrangement – multimers - 2 binding sites - Ring – neuraminidase - Filaments – actin 7. Proteins that have elongated, fibrous shapes
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Outline - Chapter 3 - C hapter 3 P roteins P rotein...

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