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Unformatted text preview: -Activation of a ubiquitin ligase e.g. APC by addition of a subunit-Signals create a degradation signal in the target protein e.g. N-end rule-In yeast – 12 destabilizing residues-Arg, lys, his, phe, leu, tyr, trp, ile, asp, glu, asn, gln 6. Abnormally folded proteins form aggregates-Resistant to proteolysis-Cross-beta filament-Prion diseases – CJD in humans, BSE in cattle-“Protein-only inheritance”...
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