BIO370lec7 - Lecture7 Populations III= Interaction of...

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Lecture 7 Populations III= Interaction of evolutionary forces
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Hardy-Weinberg Equilibrium No selection No mutation No migration (no gene flow) Large population (infinite; no genetic drift) Random mating
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Population Genetics: Studies what happens when you break the assumptions of the null (HW) model.
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The peppered moth,  Biston betularia Melanic genotype first detected in 1848 Within 50 years it spread throughout the U.K. Haldane used speed of spread to estimate a selective advantage of about 50% (s=0.5)
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Directional Selection : Selection against recessive allele Genotype Selection AA 1 Aa 1 aa 1-s Selection against dominant allele Genotype Selection AA 1-s Aa 1-s aa 1
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Heterozygote advantage: A case of balancing selection Genotype Selection AA 1-t Aa 1 aa 1-s t= selection coefficient against AA s= selection coefficient against aa
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Sickle-cell anemia ß- hemoglobin locus in humans S allele, 1 amino acid change GLU-VAL At low O 2 , S hemoglobin forms elongate crystals causing sickle cell anemia
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