8-31-11 - The egg expresses Bindin receptors mechanisms for...

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The egg expresses Bindin receptors 1. sperm binding is limited 2. Bindin receptors are sufficient for sperm binding 3. sperm binding is species specific mechanisms for species-specific interactions: -chemotaxis (Resact) -acrosome reaction -Sperm-egg adhesion: Bindin proteins
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Fusion of egg and sperm cell membranes Fertilization cone : formed in egg. -2 nd membrane fusion event - fusogenic proteins
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Fertilization Contact and recognition between sperm and egg Regulation of sperm entry: there can be only one Fusion of genetic material Activation of egg metabolism Reactivation of the cell cycle
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Prevention of polyspermy Must maintain diploid gene number in each generation 1. Fast block to polyspermy 2. Slow block to polyspermy
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The effects of polyspermy
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Fast block to polyspermy change in the membrane potential of the egg, last ~ 1min. Preventing depolarization increases polyspermy. Involvement of Bindin.
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Formation of the fertilization envelope
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8-31-11 - The egg expresses Bindin receptors mechanisms for...

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