9-2-11 - Fig II.4 fates not invariant regulative...

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Early development – cleavage, gastrulation and axis specification, oh my cleavage : increasing cell number gastrulation : generating 3 germ layers axis specification : D/V, A/P, R/L
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Dev Bio toolbox: Fate mapping p17-23 Living embryos Vital dyes Fluorescent molecules Genetic labeling (e.g chimera) Transgenic labeling
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Dev Bio toolbox: Fate mapping p17-23 Living embryos Vital dyes Fluorescent molecules Genetic labeling (e.g chimera) Transgenic labeling
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Fate mapping via genetic markers
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Fate mapping in transgenics (Chalfie, Shimomura, & Tsein were awarded the Nobel prize in 2008 for developing GFP)
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A fate map
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Fate maps are informative
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The process of differentiation Differentiation : generate specialized cell types Stages of Commitment : - Specified - Determined pgs 109-119
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Autonomous specification Fig II.1 Cytoplasmic determinants Mosaic development isolation exp.
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Conditional Specification
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Unformatted text preview: Fig II.4 fates not invariant regulative development cell-cell interactions recombination (heterotypic transplant) expt defect expt Early cleavage early cell cycles are biphasic no mRNA synthesis early cleavages are rapid, synchronous & do not increase cytoplasm levels MBT mid-blastula transition Karyokinesis & Cytokinesis Cleavage patterns Due to amount of yolk & spindle orientation Complete cleavage yolk inhibits cleavage Cleavage patterns incomplete cleavage Rotational cleavage predicts the direction of a snail shells coil Cleavage in C. elegans An invariant lineage of 959 somatic cells Radial holoblastic cleavage in the sea urchin meridional equatorial 7 stereotypic divisions Sea urchin blastula formation blastocoel 1 cell layer thick vegetal plate...
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9-2-11 - Fig II.4 fates not invariant regulative...

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