chapter_1_part1 - Chapter 1 Basic Concepts In Immunology...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 1 Basic Concepts In Immunology This chapter introduces the cellular and molecular players of the immune system (based mainly on our understanding of the immune systems of mice and humans) Components of the immune system (organs, cells, molecules) Principles of innate and adaptive immunity Recognition and effector mechanism This chapter is a summary of immunology. It provides the framework upon which the remainder of the course is built. If you do not have a solid understanding of this chapter, you will have significant difficulty following the subsequent chapters.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
In 1796 Edward Jenner infects a boy with cow pox to protect against small pox (before germ theory of disease) vacca=cow
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mid-late 1800s Robert Koch showed that microorganism cause infectious diseases and that different organisms cause different diseases Louis Pasteur first showed how vaccines could be made to a variety of bacterial and viral pathogens. 4 broad categories of pathogens (disease causing organisms): viruses, bacteria, fungi, and “parasites” (eukaryotes including protozoans and worms) Emil Von Behring and Shibasaburo Kitasato found, in the blood of immune individuals, a substance that bound to the bacteria to which they were immune. Called the substance ANTIBODY
Background image of page 4
An adaptive immune response might provide lifelong protective immunity to a given pathogen. (immune memory ) These are central principles of adaptive immunity Adaptive Immunity: Specific Immune Response (e.g., antibody ) against a particular microorganism is an adaptive immune response . That is, it occurs during one’s lifetime as an adaptation to the presence of that particular organism. (usually, specific means the ability to distinguish one organism from another) Antigen-specific responses are mediated by lymphocytes Specific immunity can be induced by a variety of substances. Things that are targets of adaptive immunity are called ANTIGENS* *Things that induce an adaptive immune response are immunogens
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Innate immunity is the immunity that is immediately available without having to adapt to the specific pathogen that is present. It is not specific to a particular organism such that identical responses can protect against several organisms. Innate immunity is germline encode (evolved on an evolutionary time scale). Innate immunity is mediated by phagocytes (cell that ingest bacteria or other particulate matter) such as macrophages and neutrophils . It is also mediated by chemical compounds and physical barriers that will be described later.
Background image of page 6
Together, innate and adaptive immunity prevent most infectious diseases (no symptoms from exposure to the microorganisms) or cure infections This course mostly deals with adaptive immunity. However, you must understand innate immunity and how adaptive immunity works together with innate immunity to prevent or cure infections.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
largely involves granulocytes and macrophages Adaptive immunity is mediated primarily by lymphocytes Cellular components of the immune system
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/22/2011 for the course BIOL 6570 taught by Professor Jenniferleavey during the Spring '11 term at Georgia Institute of Technology.

Page1 / 34

chapter_1_part1 - Chapter 1 Basic Concepts In Immunology...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online