chapter_6 - associated with CD3 ( ,, ) and (zeta) chain....

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Chapter 6 Signaling Through Immune System Receptors Ig, TCR, cytokine receptors signal transduction is the change of a signal from one form to another (i.e., passing information along in different forms)
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Two types of receptors that signal through protein kinases Kinase inactive active Kinase
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The cytoplasmic tail of the BCR does not have catalytic or signaling activity. Instead, BCRs are associated with two invariant chains, Ig α and Ig β. Aggregation or conformational changes in the Ig molecule causes changes in the Ig α and Ig β heterodimer that allow it to signal the inside of the cell that antigen has been bound by the surface Ig on the outside of the cell ag Immunoreceptor tyrosine-based activation motif (ITAM)
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Similar to BCR, the TCR alone cannot signal the T cell that it has bound antigen The TCR is always
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Unformatted text preview: associated with CD3 ( ,, ) and (zeta) chain. These molecules are involved in signaling the T cell when it engages antigen in its TCR The TCR plus CD3 is referred to as the TCR complex What cell(s) has these receptors on its surface? What is recognized by these receptors? CD4 Clustering of BCRs initiates signaling into the B cells (receptor aggregation ): aggregational signaling Also, conformational signaling ; antigen binding to the receptor changes the conformation (3D structure) of the receptor so it gains or looses reactivity; this occurs when epitopes do not repeat on an antigen In nature, BCR aggregation occurs when an epitope is repeated on one molecule (polymers) or on a surface (e.g., surface of bacteria or virus). next Slide 7 Slide 6...
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chapter_6 - associated with CD3 ( ,, ) and (zeta) chain....

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