chapter_8 - Part IV: The Adaptive Immune Response Chapter 8...

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Part IV: The Adaptive Immune Response Chapter 8 T Cell-mediated Immunity (CMI) T cells leave the thymus and circulate through the blood and lymphoid organs Naïve T cells have not reacted with their specific antigen When a naïve T cells appropriately interacts with antigen it gets activated (proliferation and differentiation). The result is that lots of antigen-specific cells acquire their effector function . That is, they become armed effector T cells that can act on target cells.
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Tissue (immature) dendritic cells (also Langerhans’ cells) ingest foreign material (and self material) (using innate mechanisms); inflammatory molecules (e.g., cytokine and bacterial products) cause their maturation. Mature dendritic cells migrate to regional lymphoid organs (e.g., lymph node). They present antigens and co-stimulatory molecules (e.g. signal 2) to T cells. Macrophages and B cells also take up foreign material but these cells are usually the targets of armed effector T cells
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T cell functions IgE for Important for MOST antibody responses. Less important for this course
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T cell recirculation and encounter with antigens Or, for some T H 1 and T H 2 cells, stay in the lymph node to help B cells responses
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T cells not specific for the immunizing antigen in efferent lymph (different scale than the antigen specific cells)
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Lymphocytes enter lymphoid organs (e.g., lymph nodes) by passing through the walls of high endothelial venules (HEV) The migration (trafficking) is mediated by cytokines/chemokines and adhesion molecules
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Activation of T H 1 cells requires antigen plus MHC and co-stimulation . This is done by professional antigen presenting cells (APCs). Dendritic cells are the primary source for activation of T H 1 and T H 2. Dendritic cells take up antigens in the periphery and get activated by bacterial products or cytokines(a), migrate to the regional lymphoid organ (b) and present antigen and co-stimulatory molecules to T cells (c). MHC II = green Lysosomal proteins= red a b c Figure 8.9 Skip this slide
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T cell are mostly in the T cell zone (but not exclusively) B cells mostly in B cell zone (but not exclusively) Interdigitating dendritic cells are primarily in the T cell areas of lymphoid organs and their primariy function is to activate T cells (T H ) (are these immature or mature dendritic cells?) B cell circulate through the lymphoid organs. Are they weak activators of naïve T cells? Macrophages mostly for filtering the lymph fluid. They are weak activators of T cells APCs in lymphoid organs ?
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This is the conventional dendritic cell that activates T cells and is what we refer to when we use the unmodified term “dendritic cell” Dendritic cell Is this an immature or mature dendritic cell? How do you know? (see slide 11)
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Langerhans cells (one type of immature dendritic cell) take-up antigen in the interstitial tissues; they begin a maturation process as they migrate via the lymphatics to the draining lymph node In the lymph node they are mature dendritic cells that present antigen to T cells (signal 1) and provide
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This note was uploaded on 09/22/2011 for the course BIOL 6570 taught by Professor Jenniferleavey during the Spring '11 term at Georgia Institute of Technology.

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chapter_8 - Part IV: The Adaptive Immune Response Chapter 8...

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