chapter_10 - Chapter 10 Dynamics of Adaptive Immunity This...

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Chapter 10 Dynamics of Adaptive Immunity This chapter tries to integrate much of what we have already covered so we can better understand how the immune system protects from infection. How infectious agents cause disease The course of an adaptive immune response Immunological memory
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If no innate immunity The course of a typical infection and adaptive immune responses can be divided into phases
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The establishment of an infection depends on several factors: Characteristics of the microorganism Number of organisms Mode of transmission (how and where they contact the host) Stability of the organism (in and outside of the host)
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Almost all infections begin at an epithelial surface* *skin or mucosal surface of the respiratory, gastrointestinal, and urogenital tract which are always exposed to microorganisms. Interstitial tissues are normally free of any microorganisms (sterile) Skin and tight junctions usually prevent penetration
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Most pathogens have developed defenses to partially escape destruction by the innate protective mechanisms listed in boxes 1 & 2 below Most pathogens cause disease in only one or a few related species because the pathogens can adhere to epithelial surfaces of only a few species or can escape innate immunity of only a few species.
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The course of the adaptive response to infection Adaptive immune response becomes important when innate immunity cannot deal with the infection within a couple of day How do infections progress in immune deficient individuals?
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The results of an immune response vary depending on the individual and the pathogen and other factors (e.g,
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chapter_10 - Chapter 10 Dynamics of Adaptive Immunity This...

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