chapter_11 - Chapter 11 The Mucosal Immune System* So far,...

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Chapter 11 The Mucosal Immune System* So far, we have covered the systemic immune system generated in lymph nodes, spleen and providing protection for most of the body except mucosal surfaces. Mucosal immune system protects most epithelial surfaces (mucus membranes: not the skin) and the tissues adjacent to these surfaces Unlike the skin, these surfaces are relatively fragile and often associated with numerous bacteria and other potential pathogens *Mucosal-associated lymphoid tissue (MALT)
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Mucosal Tissues Some (most) of these surfaces are constantly exposed to bacteria and other organisms; some of these organisms are normal flora, some are pathogens and some are neither normal flora nor pathogens
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These include infections that enter via mucosal surfaces but manifest disease in non-mucosal organs. In fact, almost all infections enter via mucosal surfaces
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lymphocytes and other cells of the immune system are found in association with the gut epithelial cells and in the lamina propria, the intestine generally appears as if it is manifesting an inflammatory response. However, this is normal and not inflamed. Organized lymphoid tissues of the gut are called
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chapter_11 - Chapter 11 The Mucosal Immune System* So far,...

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