chapter_13 - Chapter 13: Allergy and Hypersensitivity The...

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Chapter 13: Allergy and Hypersensitivity The book defines allergy as an IgE response to innocuous antigens (i.e., a type I hypersensitivity)(we will use this definition) Others define all hypersensitivities as allergies (i.e., types I to type IV) Hypersensitivity is an immune reaction to innocuous antigens that results in tissue injury and/or disease An antigen that causes allergy is an allergen Can you define allergen, immunogen, antigen?
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Four Types of Hypersensitivities
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Allergy (type I hypersensitivity mediated by IgE on mast cells)
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Dust Mite
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Mast cell degranulation by antigen (allergen) cross-linking of Fc ε R-bound IgE Eosinophils and basophils may also participate
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What are the characteristics of allergens? It is not fully understood how or why, but these type of antigens tend to stimulate IL-4 production; Il-4 production tends to lead to more IL-4 production. IL-4 favors class switching to IgE
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The enzymatic activity of a dust mite fecal protein allows it to penetrate epithelial tight junctions and induce a T H 2 response Skip this slide
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Genetics and the Environment play a significant roles in determining who has allergies and which kind of allergy. Certain allergies and autoimmunity can be mapped to specific
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chapter_13 - Chapter 13: Allergy and Hypersensitivity The...

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