INTRO_Lhandout - Outline of Talk Introduction to Molecular...

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1 Introduction to Molecular Modeling BIOL 7110 / CHEM 8901 / BIOL 4105 / 4804 January 13, 2011 Outline of Talk Structure-function relationships Molecular models: What are they? Why build them? Three themes of this course Review of units (dimensions) Review of macromolecular structure Rosalind Franklin and the diffraction pattern of B-form DNA What molecular structure is compatible with the diffraction pattern? Need a model! James Watson, Francis Crick and the model for double-helical DNA 1 nm All-atom model of DNA James Watson, Francis Crick and the model for double-helical DNA Structure held together by complementary basepairing (A–T and G–C)
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2 James Watson, Francis Crick and the model for double-helical DNA Significance: Structure-function relationship in DNA Each strand serves as a template for generation of the complementary strand. How is genetic information passed from one generation to the next? This is a model for DNA replication A model of DNA replication A C G G T … T G C C A … T G C C A T G G C A a c g g t t g c c a T G C C A … a c g g t A C G G T … t g c c a Structure-Function Relationships: A Key Concept in Biology www.thehumanbody.ecsd.net/student_gallery
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This note was uploaded on 09/22/2011 for the course BIOL 7110 taught by Professor Steveharvey during the Spring '11 term at Georgia Institute of Technology.

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INTRO_Lhandout - Outline of Talk Introduction to Molecular...

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