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Presentation 13(1) - 1 Presentation 13: Genome Sequences...

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Unformatted text preview: 1 Presentation 13: Genome Sequences and Gene Numbers Lewin’s Genes XI: Chapter 6 Genomes • What have we learned from genome sequencing projects? Large scale international efforts: • E. coli • C. elegans • Arabidopsis • Humans • Gene numbers, types, distribution • The Y chromosome • Essential genes • Genome expression = mRNA synthesis • DNA microarray technology • Personal Genomic Sequencing The face of the human genome. A scientiFc milestone of enormous proportions, the sequencing of the human genome will impact all of us in diverse ways-from our views of ourselves as human beings to new paradigms in medicine. This entire issue is devoted to the scientiFc announcement of the sequencing of the human genome, initial analyses of the genome and genomic data, as well as Viewpoints and News features discussing the implications of the results and paths for the future. 16 ¡ebruary 2001 Vol 291, Issue 5507, Pages 1145-1434 ** ** 2 average length ~950 bp average separation between genes ~118 bp ~42% of the genes have counterparts outside the Nematoda ~15% of the genes are organized into polycistronic units We do not understand why the Fy — a much more complex organism — has only 70% of the number of genes in the worm. ¡igure 6.2 Bacterial Gene Numbers Range Over an Order of Magnitude Parasitic bacteria: ~500 genes Nonparasitic bacteria: ~1500 genes 3 FIGURE 6.3 * The number of genes in bacterial and archaeal genomes FIGURE 6.4 * The number of genes in eukaryotes 4 Total Gene Number Is Known for Several Eukaryotes FIGURE 6.6: Functions are known for only half the ¡y genes Adapted from Drosophila 12 Genomes Consortium, Nature 450 (2007): 203-218. 5 How Many Different Types of Genes Are There?...
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This note was uploaded on 09/25/2011 for the course GEN 409 taught by Professor Linda during the Spring '09 term at Iowa State.

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Presentation 13(1) - 1 Presentation 13: Genome Sequences...

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