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bbmbChapter6-1 - Chapter 6 Homologous proteins Sequence...

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Chapter 6 Homologous proteins Sequence alignments 3D structure and evolutionary relationships Evolutionary trees from protein sequence Modern techniques to explore evolution
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At this point you know proteins are important (though you don’t know many details yet). How can we use the wealth of general information from genomic and proteomic research to help us understand protein function? The phenotype of an organism is very much influenced by the collection of proteins expressed in its cell(s). So understanding protein function is of the utmost importance in biochemistry right now.
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Homologs, Orthologs, and Paralogs Homology within one species (frequently different functions) Homology across species (frequently the same function) Henikoff et al. Science, 278, 1997
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How do we compare protein sequences?
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We compare every possible alignment
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Alignment “gaps” Scoring: Identity = +10 (total of 38) Gap = -25 Total score of 355 (whereas before we would have scored 220 or 230, and 16% ID)
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This note was uploaded on 09/25/2011 for the course BIOL 404 taught by Professor Dr.hargrove during the Spring '11 term at Iowa State.

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bbmbChapter6-1 - Chapter 6 Homologous proteins Sequence...

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