Biochemistry - Biochemistry 404 lcome to the most...

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Biochemistry 404 Mark Hargrove elcome to the most intriguing course you will take in colleg Dept. of Biochemistry, Biophysics, & Molecular Biology
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?
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Main points from this lecture . The importance of water and “weak forces” A reminder of pH and basic thermodynamics How will this course run? Why study biochemistry? The importance of “biochemical unity”
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Overview of Biochemistry The discipline of biochemistry seeks to explain life processes in terms of the fundamental chemical principles - growth, reproduction, senses, response to the environment, etc. Biochemistry is a reductionist approach in which specific molecules are separated from the living organism and studied in a “test tube” environment - information thus collected on thousands of biomolecules must then be integrated into a systematic understanding of life processes Biochemistry, molecular biology, cell biology, genetics are merging into an integrated field of molecular bioscience - don’t be surprised if you’ve seen some of this material in
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Organizational Themes (i) Biomolecules are often polymers assembled from repeating building block units - proteins, carbohydrates, lipids, nucleic acids The three dimensional structure of biomolecules determines their chemical and biological functions The unit of biological function is the cell, which contains both water-based chemical environments and organic molecule-based chemical environments Energy input from the environment is continually necessary to maintain the chemical reactions of life - life systems capture energy from the environment and
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Organizational Themes (ii) Ordered sets of chemical reactions, i.e., metabolic pathways, accomplish interconversions between biomolecules Chemical reactions in living systems are catalyzed by specialized proteins called enzymes Information is stored in chemical form by nucleic acids and this information ultimately determines biological function
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Why Study Biochemistry? To obtain a fundamental understanding of life - to understand the differences between living and non- living matter To advance the areas of medicine, health, nutrition, and the environment - e.g., most pharmaceuticals are discovered by the application of biochemistry information To advance other technologies though the application of biochemistry – materials science, renewable resources, biotechnology, etc.
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Main points from this lecture . How will this course run? (lets look at the syllabus)
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Historical Development of Biochemistry as a Discipline Physical and chemical sciences characterize biomolecules in chemical terms Genetics, cell biology, molecular biology identify biological functions and correlate them with specific biomolecules Fusion of the two sciences, chemistry and biology, allows explanation of life processes in terms of fundamental chemical principles Biochemistry is a young field!
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1922-1995 Clair Patterson He was from Mitchellville Iowa, and measured the age of the earth: 4.55 billion years. His work also “lead” to the Clean Air Act (1970) The earth is old.
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“prebiotic world” The roadmap of life
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Biochemical unity underlies biological diversity TATA-box binding protein
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Biochemical unity underlies biological diversity: This is one observation that supports speciation and a common biochemical understanding of biology
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General biochemistry is shared by these organisms: It doesn’t HAVE to be this way, yet it is.
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