9-6-11-4Drugs

9-6-11-4Drugs - Depressants Benzodiazepines Chloride ion C...

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DRUGS
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Questions… Why does withdrawal feel bad? Why are there individual differences in addiction? What are specific synaptic effects of various drugs?
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release release synthesis synthesis Presynapti c effects
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Stimulate receptors Block receptors Block 2 nd messengers Increase # receptors Postsynaptic effects
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Agonist/antagonist
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Agonist/antagonist
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Reuptake
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Reuptake
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Cocaine Blocks reuptake DA NE and Serotonin too
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Cocaine
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Amphetamine s release DA Reverse transporters
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Methamphetamine  
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Ritalin
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Nicotine
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Ach DA Release in NA
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VTA VTA DA Nucleus  Accumbens
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Presynaptic receptors “Neuromodulator”
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Nicotine – indirect effects DA GABA To NA Nic  - Nic -
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Epinephrine DA agonist
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Opiates release DA, but indirectly
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Opiates DA GABA Endorphin
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Tolerance & Withdrawal
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Opiate use
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Unformatted text preview: Depressants Benzodiazepines Chloride ion C E - 70 mV C = E Cl- Chloride ion C E - 60 mV Cl- Chloride ion C E - 60 mV C > E Cl- Chloride ion C E - 70 mV C = E Cl-Alcohol Affects multiple NT systems nerve cell excitability GABA Glutamate receptor NMDA receptors Calcium channels Sedation Alcohol withdrawal Upregulation NMDA receptors No alcohol Alcohol firing upregulation No alcohol...
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This note was uploaded on 09/25/2011 for the course PSYCH 310 taught by Professor Dr.morris during the Spring '11 term at Iowa State.

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9-6-11-4Drugs - Depressants Benzodiazepines Chloride ion C...

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