9-20-11BrainDamage

9-20-11BrainDamage - Retrograde Degeneration Retrograde...

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What happens after a stroke?
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Stroke
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Clot stops flow of O 2 & glucose
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Kills off Na+-K+ Pump
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K + Na + Out In Na + Na + K + K + K + K + Na + Na +
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K + Na + Out In Na + Na + K + Na + Na + K + K + K +
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Axon terminal GLU
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K+ Axon terminal K+ K+ K+ K+
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Axon terminal K+ K+ K+ K+ K+ K+ K+ K+ K+
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K+ Axon terminal K+ K+ K+ K+ K+ K+ K+ K+ GLU
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K+ Axon terminal K+ K+ K+ K+ K+ K+ K+ K+ Excess glutamate release
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Excess glutamate release Excitotoxicity
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Excitotoxicity Too much Ca 2+ enters cells
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NMDA receptor
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NMDA receptor blockers?
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NMDA receptor activity Post CHI
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Retrograde Degeneration
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Retrograde Degeneration
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Unformatted text preview: Retrograde Degeneration Retrograde Degeneration Anterograde Degeneration Anterograde Degeneration Anterograde Degeneration Anterograde Degeneration Denervation supersensitivity Normal Denervation Upregulation Supersensitivity Supersensitivity Supersensitivity Recovery Astrocytes Astrocytes NGF Astrocytes NGF Locus coeruleus NE Locus Locus coeruleus coeruleus Norepinephrine Norepinephrine...
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This note was uploaded on 09/25/2011 for the course PSYCH 310 taught by Professor Dr.morris during the Spring '11 term at Iowa State.

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9-20-11BrainDamage - Retrograde Degeneration Retrograde...

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