CHAPTER 11 - CHAPTER 11 CHEMOTHERAPY 1 Twenty months after...

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Unformatted text preview: CHAPTER 11 CHEMOTHERAPY 1. Twenty months after finishing her chemotherapy, the woman had a relapse of breast cancer. The cancer was now unresponsive to standard doses of chemotherapy. The decision was made to treat the patient with high-dose chemotherapy followed by autologous stem cell transplantation. Which of the following drugs is most likely to be used to mobilize the peripheral blood stem cells for the patient’s autologous stem cell transplantation? (a) Erythropoietin (b) G – CSF (c) Interleukin - 11 (d) Intrinsic factor (e) Thrombopoietin 2. The combination of trimethoprim and sulfamethoxazole is effective against which one of the following opportunistic infections in the AIDS patient? (a) Disseminated herpes simplex (b) Cryptococcal meningitis (c) Toxoplasmosis (d) Oral cnadidiasis (e) Tuberculosis 3. The top four most commonly diagnosed cancers include all of the following except (a) Lung (b) Prostate (c) Colon and rectum (d) Thyroid (e) Breast 4. A 31-year-old man has gonorrhea. He has no drug allergies, but he recalls that a few years ago while in Africa he had acute hemolysis following use of an antimalarial drug. The physician is concerned that the patient has an accompanying urethritis due to C trachomatis, though no cultures or enzyme tests have been performed. Which of the following drugs is most likely to be effective against gonococci and to eradicate C trachomatis in this patient? (a) Cefixime (b) Ciprofloxacin (c) Ofloxacin (d) Spectinomycin (e) Sulfamethoxazole 5. The mechanism by which sulfasalazine exerts its primary action in ulcerative colitis is inhibition of (a) Folic acid synthesis (b) The formation of leukotrienes and prostaglandins (c) Phospholipase C (d) Proton pump activity (e) The formation of interleukind 6. Which one of the following adverse effects is most likely to occur with sulfonamides? (a) Neurologic effects, including headache, dizziness, and lethargy (b) Hematuria (c) Fanconi’s aminoaciduria syndrome (d) Kernicterus in the newborn (e) Skin reaction 168 MCQs IN PHARMACOLOGY 7. This drug is the preferred agent for teatment of nocardiosis and, in combination with pyrimethamine, is prophylactic against preumocystis carinii infections in AIDS patiens. (a) Ampicillin (b) Clindamycin (c) Norfloxacin (d) Sulfadiazine (e) Trimethoprim 8. Supplementary folinic acid may prevent anemia in folate-deficient persons who use this drug; it is a weak base, and achieves tissue levels similar to those in plasma (a) Ciprofloxacin (b) Norfloxacin (c) Sulfacetamide (d) Trimethoprim (e) Trovafloxacin 9. I t is now recommended that trovafloxacin be reserved for treatment of life-threatening infections because (a) Bacterial resistance to the drug is very common (b) Complete liver failure has occured (c) It is very expensive (d) Its use is associated with torsade de pointes (e) Nephrotoxicity is dose-limiting 10. The primary reason for the use of drug combinations in the treatment of tuberculosis is to (a) Ensure patient compliance with the drug regimen (b) Reduce the incidence of adverse effects...
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This note was uploaded on 09/23/2011 for the course ECON 103 taught by Professor Coley during the Spring '11 term at Tarrant County.

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CHAPTER 11 - CHAPTER 11 CHEMOTHERAPY 1 Twenty months after...

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