Is_it_substitution_or_elimi - bold means principle reaction...

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Is it substitution or elimination? Take some of the guesswork out of your decision. This table, in conjunction with the notes that follow, will help you decide. 2 o 3 o 1 o benzylic S N 2 S N 2 ((S N 2)) S N 2 Strong Nü Strong Nü Strong Nü High [Nü] High [Nü] High [Nü] C + C + C + S N 1 S N 1 S N 1 Weak Nü Weak base Weak Nü Low [Nü] Low [Nü] Low [Nü] Polar solvent Polar solvent Polar solvent E1 E1 ((E1)) Weak base Weak base (E 2 ) E2 E2 Strong base Strong base ( ) = less readily than other alkyl halides
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Unformatted text preview: bold means principle reaction a strong base is usually a good nucleophile e.g. OH-and the alkoxide ions a strong base favours E1 strong nucleophile = -CN and S N 2: weak nucleophile = H 2 O and S N 1 S N 1 favoured by very polar solvents e.g. water S N 2 favoured by polar solvents that do not solvate the nucleophile High [Nü] or base favours S N 2 or E2 Low [Nü] favours S N 1 or E1...
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This note was uploaded on 09/24/2011 for the course BIO 100 taught by Professor John during the Spring '11 term at Harvard.

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