Nucleophilic Substitution

Nucleophilic Substitution - Table of Physical Properties...

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Table of Physical Properties for Investigation of S N 1 and S N 2 Reactions M.W. M.P. B.P. DEN. SOL. HAZARD 1-butanol 74.12 -89.5 117.6 0.81 Ac, Bz,EtOH,Et 2 O 1 0 3 2-butanol 74.12 -114.7 99.5 0.808 W,Al,eth 1 0 3 t-butylalcohol 74.12 25.6 82.41 0.781 W,Al 1 0 3 t-amylalcohol 88.15 -12 102 0.805 W,Al 1 0 3 Benzylalcohol 108.14 -15.19 204.7 1.042 W,eth Al,eth,petr eth 2 0 1 Phenol 99.11 40.85 182 1.071 W,Bz,Al,Chlor,eth,petr 2 0 3 1-chlorobutane 92.57 -123 78.5 0.8865 Al,eth 2 0 3 2-chlorobutane 92.57 -140 68 0.871 W,Al,eth 2 0 3 t-amylchloride 106.59 -74 83 0.865 W,Al,eth 2 0 3
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t-butylchloride 92.57 -26.5 51.0 0.847 W,Al,eth 2 0 3 Benzylchloride 126.59 -43 179 1.10 Al, chl,eth 2 0 2 Chlorobenzene 112.56 -45 131 1.107 Al,Bz,Chl,eth 2 0 3 1-bromobutane 137.02 -112 101.3 1.269 Al, Eth 2 0 3 2-bromobutane 137.02 -112 91.2 1.253 Al,eth 2 0 3 t-butylbromide 137.02 -16.3 73.3 1.2125 Org.solvent 2 0 3 Benzylbromide 171.04 -3.9 198 1.4380 Et 2 O,eth 3 0 3 Bromobenzene 157.01 -31 156 1.491 Chl,Bz,Al,eth,petr carbons 2 0 2
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Investigation of S N 1 and S N 2 Reactions If a positive result does not occur in 1 min, continue timing but start a test on a new compound ( i. e . do experiments in parallel). PART A: REACTIVITY OF BROMIDES TOWARD SODIUM IODIDE. Sodium Iodide in acetone. In this part of the experiment you will test the reactivity of several alkyl halides under S N 2 conditions. In acetone solution, other alkyl halides can be converted to alkyl iodides. Although we might expect such a reaction to be reversible, it can be driven forward by using anhydrous acetone as the solvent. Sodium iodide is soluble in this solvent, whereas sodium chloride and sodium bromide are not. If a reaction occurs, a precipitate of sodium bromide or sodium chloride will form. Directions
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This note was uploaded on 09/24/2011 for the course BIO 100 taught by Professor John during the Spring '11 term at Harvard.

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Nucleophilic Substitution - Table of Physical Properties...

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