Lecture5 - 282 Lecture 5 – September 21, 2011...

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Unformatted text preview: 282 Lecture 5 – September 21, 2011 Electrophilic Aromatic Substitution Reaction Reactions of Alkyl Substituents 2 Electrophilic Aromatic Substitution Reactions - general mechanism - 3 Halogenation of Benzene v bromination or chlorination of benzene requires a Lewis acid catalyst such as ferric bromide or ferric chloride v the Lewis acid is needed to make Br 2 (or Cl 2 ) a better electrophile 4 Halogenation of Benzene 5 Nitration and Sulfonation of Benzene Sulfonation is the only aromatic electrophilic substitution reaction that is reversible 6 Friedel-Crafts Reactions u g e t a n " A c c e s s R e s t r i c t e d " m e s s a g e , y o u c a n l o g i n t o a u t h e n t i c a t e w i t h E Z- P Charles Friedel 1832-1899 James Mason Crafts 1839-1917 They collaborated scientifically for most of their lives, discovering the Friedel-Crafts reactions in Friedel ’ s laboratory in 1877 v two electrophilic substitution reactions bear the names of the two chemists v Friedel-Crafts alkylation places an alkyl group on a benzene ring...
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This note was uploaded on 09/25/2011 for the course CHEM 282 taught by Professor Nabylmerbouh during the Spring '10 term at Simon Fraser.

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Lecture5 - 282 Lecture 5 – September 21, 2011...

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