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AldKetones_notes

AldKetones_notes - s i s o f n i t r i l e g r o u p f o l...

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Relative reactivities of carbonyl compounds towards nucleophiles: An aldehyde has a greater partial positive charge on its carbonyl carbon than does a ketone • Steric factors contribute to the reactivity of an aldehyde • The carbonyl carbon of an aldehyde is more accessible to the nucleophile • Ketones have greater steric crowding in their transition states and in the final products, so they are less reactive General trend in reactivities of carbonyl compounds: acyl halide > acid anhydride > aldehyde > ketone > > ester ~ carboxylic acid > amide > carboxylate anion
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