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3813-002Day9posted - Glycosidic bonds Peptide Bonds Note...

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MBIO 3813-002 Day 9 Mon 9/12/11
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topics Characterizing Microbial Cell, cont’d Cell wall structures: peptidoglycan Teichoic acids Lipopolysaccharide (aka endotoxin) Exam: 8:15 can start, or 8:30
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Bact: Gram-(-) vs. Gram-(+) Their Structural Differences one of major themes in microbiology PG present G-(+): Thick, multi-layered, peptide interbridge between struts G-(-): Thin, few layers “Decorations” on and in cell wall (cont’d)
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Fig 3.18 NAG-NAM -NAG-NAM-
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Unformatted text preview: Glycosidic bonds Peptide Bonds Note: L-Ala and D-Ala and D-Glu G-(+) will have interbridge, lengthening this Protein struts, cont’d • Penicillin-sensitive bond formation - link between the pentapeptides does not form, β-lactams inhibit reaction • Gram-positive cell PG: there are additional AA in a peptide between the two pentapeptides – ( e.g. a pentaglycine interbridge), cell wall is less tightly packed than in Gram-neg...
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