3813-002Day9printed - Glycosidic bonds Peptide Bonds Note:...

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1 MBIO 3813-002 Day 9 Mon 9/12/11 topics Characterizing Microbial Cell, cont’d – Cell wall structures: peptidoglycan – Teichoic acids – Lipopolysaccharide (aka endotoxin) • Exam: 8:15 can start, or 8:30 Bact: Gram-(-) vs. Gram-(+) • Their Structural Differences one of major themes in microbiology • PG present G-(+): Thick, multi-layered, peptide interbridge between struts G-(-): Thin, few layers “Decorations” on and in cell wall (cont’d)
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2 Fig 3.18 NAG-NAM -NAG-NAM-
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Unformatted text preview: Glycosidic bonds Peptide Bonds Note: L-Ala and D-Ala and D-Glu G-(+) will have interbridge, lengthening this 3 Protein struts, contd Penicillin-sensitive bond formation - link between the pentapeptides does not form, -lactams inhibit reaction Gram-positive cell PG: there are additional AA in a peptide between the two pentapeptides ( e.g. a pentaglycine interbridge), cell wall is less tightly packed than in Gram-neg...
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3813-002Day9printed - Glycosidic bonds Peptide Bonds Note:...

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