(d)A methoxy group is ortho, para-directing, and a carbonyl group is meta-directing. The openpositions of the ring that are activated by the methoxy group inp-methoxyacetophenone arealso those that are meta to the carbonyl, so the directing effects of the two substituents reinforceeach other. Nitration ofp-methoxyacetophenone yields 4-methoxy-3-nitroacetophenone.(e)The methoxy group of p-methylanisole activates the positions that are ortho to it; the methylactivates those ortho to itself. Methoxy is a more powerful activating substituent than methyl,so nitration occurs ortho to the methoxy group.(f)All the substituents in 2,6-dibromoanisole are ortho, para-directing, and their effects are felt atdifferent positions. The methoxy group, however, is a far more powerful activating substituentthan bromine, so it controls the regioselectivity of nitration.12.18The product that is obtained when benzene is subjected to bromination and nitration depends on theorder in which the reactions are carried out. A nitro group is meta-directing, and so if it is introduced
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This note was uploaded on 09/26/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.