position that is ortho to the chlorine puts it meta to the carboxyl and meta to thefrst nitrogroup.(b)An amino group is one of the strongest activating substituents. The para and both ortho posi-tions are readily substituted in aniline. When aniline is treated with excess bromine, 2,4,6-tribromoaniline is formed in quantitative yield.(c)The positions ortho and para to the amino group in o-aminoacetophenone are the ones mostactivated toward electrophilic aromatic substitution.(d)The carboxyl group in benzoic acid is meta-directing, and so nitration gives m-nitrobenzoicacid. The second nitration step introduces a nitro group meta to both the carboxyl group andthe frst nitro group.(e)Both bromine substituents are introduced ortho to the strongly activating hydroxyl group in
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This note was uploaded on 09/26/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.