NPB168-lecture3

NPB168-lecture3 - metabolic induction - one of the effects...

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Sheet1 Page 1 metabolic induction - one of the effects of the drug is to effect the enzyme itself when i shoot up cocain IV it's only going to my brain? no - going according to the bus system, it literally goes everywhere but where is there an effect? - anywhere there's an active binding site for that drug. Even the inactive binding sites have a rela with the actual site of the drug. Each binding site would create its own effect. Some drugs causes metabolic induction - causing a positive feedback loop, causing an increase in their activity metabolic inhibition - making it harder for the enzymatic system to break down stuff. How is the justice system affecting the absorption of the drug? effect the acidity of the drug. First pass metabolism -drugs must tolerate an acidic environment -drug must cross SI epithelium where it may see its 1st enzymes -must pass thru liver (1st site of metabolism ) before entering systemic circulation -depot binding Drug tolerance Def:Progressively decreasing responsiveness to subsequent administrations
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This document was uploaded on 09/29/2011.

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NPB168-lecture3 - metabolic induction - one of the effects...

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