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Unformatted text preview: -img pig ileum intestine Relative potencies of Opioid Analgesics Perfect correlation R=1 (a)Localization of mu receptors-mostly widely distributed-analgesia - medial thalamus, periaqueductal gray, median raphe, spinal cord-reinforcement-nucleus accumbens(NAc)-limbic-autonomic function-brain stem, medulla, area postretia (b)Localization of delta receptors-more restricted distribution-olfaction (bulbs)- motor integration neocortex, striatum substantia-reinforcement NAc (c)Localization of kappa receptors-most restricted distribution-analgesia - periaquductal gray(PAG), raphe nuc., spinal cord, locus coeruleus-horizontal control-temperature, thirst, food intake,-hypothalamus and pituitary Sheet1 Page 2-disphoria-amygdala, NAl...
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- Spring '08