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Unformatted text preview: Sheet1 Page 1 Identification of BMP5 as the inhibitor-came out of studies focused on determining if neural induction is similar to Drosphilia and vertebrates-Drosophilia experiments identified an inducer similar to chordin-this led to experiments to identify genetic interactors with chordin and to the ultimate indentification of A BMP-like protein as t-Subsequent studies in Xenopus looked at BMP family members were expressed during grastrulation BMP4 is expressed throughout most of the gastrula, but at reduced levels in the organizer and neurogenic animal cap. expect neural inducers in the IMZ, and the inhibitors to be least concentrated there.-most important recombinant BMP4 can suppress neural induction by chordin. Conclusions: (1)the dorsal-ventral axis of the developing embryo uses similar mechanisms in fly and vertebrate (2)Neural inducers all act through a common mechanism to antagonize BMP4 signaling. Evidence that neural inducers act through a common mechanism to antagonize BMP4 signaling (1)BMP4 will inhibit neural differentiation of animal caps treated with chordin or noggin (2)BMP4 will inhibit neural differentiation of dissociated animal caps (3)Antisense BMP4 RNA causes neural differentiation of animal caps without addition of any of the inducers-the expression of the truncated activin receptor also blocks BMP4 signaling The current model of neural induction in amphibian embryos: Neural induction is actually reversal of inhibition The involuting mesodermal cells of the IMZ release several molecules that interfere with the BMP signals between ectoderma Ceberus, chordin, noggin, and follistatin all interfere with the activation of BMP recptor by the BMPs in the ectoderm and there the anti-neuralizing effects of BMP4. In other words, they "induce" this region of the embryo to develop as neural tissue, ultim the brain, spinal cord, an most of the peripheral nervous system....
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This note was uploaded on 09/29/2011 for the course NPB 161 taught by Professor Kimberleymcallister during the Spring '11 term at UC Davis.
- Spring '11