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Unformatted text preview: Prelim 1 Review: Hamlet- how does he talk about his feelings? Very expressive about emotions and physical experience of his feelings- Ophelia talking about his coming to her bedroom- Who is Claudius? What kind of person will murder his brother and seduce his brothers wife? But even Claudius reflects on his crimes but he wishes he can repent but he wont Axis 4- what are the issues that are plaguing the person? Axis 5- the value 1-100 The Brain, Neurons and Neurotransmitter, & Mood How Drugs Enter the Body 1. Kinds of Drugs 2. By mouth, injection, breathing 3. Crossing the Blood Brain barrier- the problem is that it must cross the blood-brain barrier- the way drugs effect you only depend on how your bodys blood- brain barrier is, it doesnt matter how large you are 4. lipid soluble drugs 5. switching on a neuron Crossing the Blood-Brain Barrier 1. Depends on lipid-soluble drugs (lipids are fatty molecules that can pass through cell membranes) 2. Everyones brain barrier is slightly different, making it difficult to know the dosage of, say, an antidepressant drug, for any given person Now, once the drug has reached the brain, how do they work on individual neurons? Answer: receptors take in the drug, which either affects the neuron directly (by making it fire) or by turning on genes which, in turn, produce proteins, changing the functioning of that neuron Neurons & how they work:- they are alive! Change, build parts, complicated, fed by glial cells, around 10 billion, connect and communicate, allow us to store things in me mory, think, everything. First: what they look like:- cell body with nucleus (DNA) with axons and dendrites- each neuron can generate different features, very flexible- different shapes o retinal bipolar cell o retinal ganglion cell o retinal amacrine cell o cortical pyramidal cell o cerebella purkinje cell (from cerebellum) Second, How theyre built:- have fluid inside (cytoplasm) and outside (extracellular fluid)- containing energy with ATP- myelin coating made by glial cells- the thicker the coating the faster the conduction of electrical signals- chromosomes insides (long strands of DNA) Firing and Changing 1. Neurons either change the polarity of other neurons by flooding them with ions until they fire or 2. They send neurotransmitters into the synapses between the 2....
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- Spring '08