March 13 - Lecture 16 3/13 When Schizophrenia Starts, How...

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Lecture 16 3/13 When Schizophrenia Starts, How it Appears, What is a Schizotype, & The Limits of Medication Schizophrenia: The Neurodevelopmental Disorder 1) Start with a genetic liability 2) Add intrauterine trauma, infection, stress 3) Add environmental, psychological stress 4) And you have a “schizotype” someone expressing some symptoms of neurological deficits, or … 5) prodromal or acute onset schizophrenia after puberty… eye-tracking problems slightly genetically expressed schizo symptoms, but not full-blown If only a fraction of people with schizophrenic liability develop schizophrenia … Then we don’t have to study only people with schizophrenia. We can study people with schizophrenic liability … we call them schizotypes , and the ways that they differ from healthy comparison subjects are called endophenotypes . Important because it is hard to observe people with schizophrenia, can’t observe them off medication, people with different types, on different medications
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March 13 - Lecture 16 3/13 When Schizophrenia Starts, How...

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