EBME 306 LECTURES #9-10-FALL-2011-ZIATS compressed

EBME 306 LECTURES #9-10-FALL-2011-ZIATS compressed -...

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BIOLOGICAL CONSTRAINTS in USING BIOMATERIALS: HEMOSTASIS & THROMBOSIS Readings for September 21 and 23: Biomaterials: The Intersection of Biology and Materials Science , J.S. Temenoff and A.G. Mikos, Pearson/Prentice Hall, 2008, pp.228-231, 280-281, 428-439
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Blood Components
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Normal Blood Smear Eos PMN Baso Mono Lympho Platelet
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Hematopoeisis TPO EPO INTERLEUKINS INTERLEUKINS CSF CSF
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Platelets
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Hemostasis & Thrombosis Hemostasis - “the stopping of hemorrhage or bleeding” Thrombosis - “ hemostasis in the wrong place”, really a pathological state of hemostasis due to intravascular clot (thrombus) formation
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Hemostasis Factors contributed by: Endothelium Biomaterial surface Platelets Blood Clotting Factors
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Hemostasis & Thrombosis Virchow’s Triad BLOOD FLOW SURFACE
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Hemostasis & Thrombosis BIOMATERIAL SURFACE or Virchow’s Triad
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Wall Shear Stress
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Hemostasis & Thrombosis Nonthrombogenic Negative charge Prothrombogenic
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Hemostasis & Thrombosis
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Defective aggregation Defective adhesion Disorders of Primary Hemostasis
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Platelets & Biomaterials ADHESION AGGREGATION RELEASE
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PLATELETS and BIOMATERIALS ADHESION AGGREGATION RELEASE vWF, collagen materials? Fibrinogen Many: Thrombin, Txb2 ADP, fibrinogen, PF4, β TG, Ca +2 GpIb GpIIb/IIIa
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Platelet-Material Interactions PDMS Dacron
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Arachidonic Acid Pathway Thromboxanes vs. Prostacyclin
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Blood Surface Interactions Albumin IgG Fibrinogen Others
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Blood Clotting Factors Made in Liver Endothelium Liver
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