STUDY QUESTIONS for Lectures 9-10, HEMOSTASIS, THROMBOSIS and BIOMATERIALS 1. What factors are involved in normal hemostasis? What is the difference between primary and secondary hemostasis? What is Virchow’s triad? 2. Describe the reaction of platelets with the vascular wall and or biomaterials. What factors are involved in adhesion, aggregation and the release reaction? What are the major glycoproteins involved in platelet adhesion and/or aggregation. What arachidonic acid pathway molecules are involved in platelet responses and what opposes their response? 3. Describe the major highlights of the clotting system? Differentiate between the extrinsic and intrinsic pathways. Where are most of the clotting factors made? What is fibrinogen? Fibrin? Thrombin? What is fibrinolysis? What enzymes are involved in fibrinolysis? 4. What are the contact factors? 5. What controls blood clotting? How is blood clotting measured? What are the important tests? What factors beside the normal clotting proteins are necessary for clotting? 6.
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