Unformatted text preview: Genetics 380 : Spring 2011 Problem Set 14
Population Genetics Problems
(Do not have to turn in the answers) 1. A population has 8-times as many heterozygotes as homozygous recessives. What is the frequency
of the recessive allele? 2. Three alleles of a gene are found in a population. The genotype of 250 individuals in the population
was determined. The distribution of genotypes is given below a. Calculate the frequencies of M1, M2, and M3 alleles in this population.
b. Using a chi-square test, determine whether the genotypes are in Hardy-Weinberg equilibrium
(assume df=3). Genotype Individuals
M1 M1 8
M1 M2 34
M2 M2 20
M1 M3 52
M2 M3 75
M3 M3 61 Total = 250 3. A completely recessive allele which is selectively neutral (frequency=0.5) becomes lethal due to a
change in the environment.
a. What was the genotype distribution when the recessive genotype was not selected against?
b. What will be the allelic frequency after one generation in the new altered environment?
c. What will be the allelic frequency after 2 generations? 4. One normal allele in 30,000 mutates to the X-linked recessive allele for hemophilia in each human
generation. Assume that 1 hemophilia allele in 1 million reverts to the wt (normal) allele per
generation. Determine the allelic frequencies for the wt (+) and the hemophilia allele (h) at
equilibrium. Assume that all other factors (migration, inbreeding, genetic drift, etc.) have no
influence on the equilibrium values of the 2 competing alleles. ...
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