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Problem Set 5 Answers - Genetics 380 Spring 2011 Problem...

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Genetics 380: Spring 2011 Problem Set # 5 Answers 1. (a,b,c) AAA (Lys)-> AAU Asn AAC Asn AAG Lys (Silent mutation; amino acid not changed) AUA Ile ACA Thr AGA Arg UAA Stop (Nonsense mutant) CAA Gln GAA Glu (d) AAG, AGA and GAA are transition mutations AAU. AAC, AUA, ACA, UAA, and CAA are transversion mutations. 2. (a) Recombination between 2 transposons in the same chromosome in direct orientation results in the loss of one copy of the transposon and all of the DNA between the 2 transposons. In other words, either transposon 1 or transposon 2 in Fig. (a) and genes numbered 1 to 10 will be lost. A circular DNA intermediate is created which lacks a centromere. As a result, it will not be partitioned properly in mitosis and will ultimately be lost. See Fig. 8.14 (A) on p. 271 of the Hartl-Jones textbook for details. (b) When 2 transposons in the same chromosome are orientated in inverse orientation (Q. 2 fig. (b):the left transposon is oriented ABCD while the right transposon is oriented DCBA), a
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