Lecture 1 - Genetics 380 1. Contact a. Navin Sinha B408,...

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Genetics 380 1. Contact a. Navin Sinha B408, Nelson Hall – sinha@biology.rutgers.edu b. Office Hours – Mondays 2-4PM – Fridays 11AM – 1PM 2. Experiments a. Griffith i. Rough (live) and smooth (die) ii. Something in heat killed S cells – that if mixed with Rough cells would change to kill – Rough cells became infectious b. Avery i. Protenase and Rnase had no effect ii. If you destroy DNA (dnase) then genetic transformation is lost iii. Transformation involves DNA c. Hershey i. Isotope experiment – Phosphate (Protein – Sulfate) ii. Add DNA goes in and protein goes in a little iii. DNA is what causes infection by the virus 3. DNA a. A-T | G-C b. Phosphorus – sugar backbone (hydrophilic) c. Base (hydrophobic) d. 3.4 Angstrom form base pairs (without kink around 6) i. Its kinky to avoid water getting in the middle e. Forces holding them i. Hydrogen bonding, stacking interactions (to avoid water) f. They run antiparallel 4. Replication a. Pull it apart and lay down nucleotides to get a copy of the
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This note was uploaded on 09/29/2011 for the course GENETICS 380 taught by Professor Glodowski during the Spring '08 term at Rutgers.

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Lecture 1 - Genetics 380 1. Contact a. Navin Sinha B408,...

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