lecture 8_DNA - DNA Structure 5′ end 3′ end...

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Unformatted text preview: DNA Structure 5′ end 3′ end Sugar-phosphate backbone • CHON and P Base pair (joined by hydrogen bonding) • DNA polymer of nucleotides • Nucleotide = nitrogenous base (A-G-T-C) + pentose sugar + phosphate group Old strands Nucleotide about to be added to a new strand The DNA double helix 5′ end New strands 5′ end 3′ end 5′ end RNA Structure • Differs from DNA – single stranded – ribose sugar not deoxyribose Central dogma of DNA 3′ end DNA Synthesis of mRNA in the nucleus mRNA NUCLEUS CYTOPLASM – uracil U base replaces thymine T base replaces thymine • Types of RNA mRNA Movement of mRNA into cytoplasm via nuclear pore Ribosome – messenger mRNA – ribosomal rRNA – transfer tRNA Watson J D, Crick F H (1953) Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid. Nature 171: 737-738. Synthesis of protein Polypeptide Amino acids Watson J.D. and Crick F.H.C. 1953 Genetical Implications of the structure of Deoxyribonucleic Acid. Nature 171, 964-967. 1 Maurice Wilkins with X-ray crystalographic equipment about 1954 Photo 51 x-ray diffration of wet DNA showing the B form double helix taken by Rosalind Franklin 2 ...
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This note was uploaded on 09/29/2011 for the course BIO 121 taught by Professor Pazymino during the Fall '08 term at UMass Dartmouth.

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lecture 8_DNA - DNA Structure 5′ end 3′ end...

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