05-ReceptorsS11b

05-ReceptorsS11b - Cell receptors Lecture 05/Chapter 9 Cell...

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Cell receptors Lecture 05/Chapter 9
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2 Cell communication Communication between cells requires: Ligand : the signaling molecule Receptor protein : the molecule to which the ligand binds Ligand-receptor binding conveys information Initiates a response through signal transduction
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Cell communication 3
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4 Signal transduction Signal transduction : the sequence of events within the cell that occur in response to ligand binding Transmitting & relaying the signal Different cell types can respond differently to the same signal
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5 Cellular responses Signaling can control activities in the cell Growth, maturation, gene expression, metabolism, death Response to ligand binding often involves making new proteins activate or serve as transcription factors Control of gene expression Cells can also respond by activating or inactivating proteins Modification of proteins: cleavage, methylation, phosphorylation, etc.
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Phosporylation e° ° A kinase e° ° adds a phosphate group to another protein Some kinases are cytoplasmic ±L ¤ · , some double as membrane receptors 6 Figure 9.3
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Receptor types Receptors can be defined by their location 1. Nuclear ( cytoplasmic ) receptor Located within the cell/ intracellular location 2. Cell Surface/membrane receptor Have intracellular & extracellular domains Bind a ligand outside the cell 7
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