Chapter%204%20MDM

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Unformatted text preview: Click to edit Master subtitle style Lecture Connections 4 | 3D Structure of Proteins 2009 W. H. Freeman and Company Structure of Proteins Unlike most organic polymers, protein molecules adopt a specific 3-dimensional conformation in the aqueous solution. This structure is able to fulfill a specific biological function This structure is called the native fold The native fold has a large number of favorable interactions within the protein There is a cost in conformational entropy of folding the protein into one specific native fold Favorable Interactions in Proteins Hydrophobic effect Release of water molecules from the structured solvation layer around the molecule as protein folds increases the net entropy Hydrogen bonds Interaction of N- H and C= O of the peptide bond leads to local regular structures such as -helixes and & -sheets London dispersion Medium-range weak attraction between all atoms contributes significantly to the stability in the interior of the protein Electrostatic interactions Long-range strong interactions between permanently charged groups Salt-bridges, esp. buried in the hydrophobic environment strongly stabilize the protein Peptide Bond 3...
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