Ch35_39_ec_reading_9(2009030500032659) - Extra Credit...

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Extra Credit Reading No it’s not about plants (except peanuts, maybe)!!! The first 2 articles are about pharmacogenetics—using knowledge about specific genes to tailor treatment with medications. The first article is about the gene in question (focus on the parts of the article that you can understand—which should be most of it!), and the 2 nd article is about human applications. Coumarin derivatives = the medication warfarin; and yes, we use this here in the U.S. as rodent killer and in medicine to treat people with certain thromobotic diseases, which are diseases in which the blood clots abnormally (clots form when they shouldn’t). Strokes are an example of abnormal blood clotting. The 3 rd article is about Salmonella. Research article  Novel mutations in the VKORC1 gene of wild rats and mice – a  response to 50 years of selection pressure by warfarin? Simone Rost 1   Hans-Joachim Pelz 2   Sandra Menzel 1   Alan D MacNicoll 3   Vanina León 4   Ki-Joon  Song 5   Thomas Jäkel 6   Johannes Oldenburg 7   and  Clemens R Müller 1   1 Department of Human Genetics, University of Wuerzburg, Wuerzburg, Germany 2 Federal Research Centre for Cultivated Plants – Julius Kuehn-Institute, Vertebrate Research, Toppheideweg 88, 48161  Muenster, Germany 3 Central Science Laboratory, Sand Hutton, York, UK 4 Department of Ecology, Genetics and Evolution, Faculty of Exact and Natural Sciences, Buenos Aires University,  Buenos Aires, Argentina 5 Department of Microbiology, College of Medicine, Bank for Pathogenic viruses, Korea University, Seoul, Korea 6 GTZ Office Bangkok, 193/63 Lake Ratchada Bldg., 16th Floor, New Ratchadapisek Road, Bangkok 10110, Thailand 7 Institute of Experimental Haematology and Transfusion Medicine, University of Bonn, 53105 Bonn, Germany author email  corresponding author email BMC Genetics  2009,  10: 4doi:10.1186/1471-2156-10-4 The electronic version of this article is the complete one and can be found online at: 2156/10/4 Received: 3 April 2008 Accepted: 6 February 2009 Published: 6 February 2009 © 2009 Rost et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License  ( ), which permits unrestricted use, distribution, and reproduction in any medium,  provided the original work is properly cited.
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Abstract Background Coumarin derivatives have been in world-wide use for rodent pest control for more than 50 years. Due to their  retarded action as inhibitors of blood coagulation by repression of the vitamin K reductase (VKOR) activity, they are  the rodenticides of choice against several species. Resistance to these compounds has been reported for rodent 
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This note was uploaded on 09/29/2011 for the course BIO 020.152 taught by Professor Pearlman during the Fall '08 term at Johns Hopkins.

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Ch35_39_ec_reading_9(2009030500032659) - Extra Credit...

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