Extra Credit Reading
No it’s not about plants (except peanuts, maybe)!!!
The first 2 articles are about pharmacogenetics—using knowledge about specific genes to tailor
treatment with medications.
The first article is about the gene in question (focus on the parts of
the article that you can understand—which should be most of it!), and the 2
article is about
Coumarin derivatives = the medication warfarin; and yes, we use this here
in the U.S. as rodent killer and in medicine to treat people with certain thromobotic diseases,
which are diseases in which the blood clots abnormally (clots form when they shouldn’t).
Strokes are an example of abnormal blood clotting.
article is about Salmonella.
Novel mutations in the VKORC1 gene of wild rats and mice – a
response to 50 years of selection pressure by warfarin?
Alan D MacNicoll
Clemens R Müller
Department of Human Genetics, University of Wuerzburg, Wuerzburg, Germany
Federal Research Centre for Cultivated Plants – Julius Kuehn-Institute, Vertebrate Research, Toppheideweg 88, 48161
Central Science Laboratory, Sand Hutton, York, UK
Department of Ecology, Genetics and Evolution, Faculty of Exact and Natural Sciences, Buenos Aires University,
Buenos Aires, Argentina
Department of Microbiology, College of Medicine, Bank for Pathogenic viruses, Korea University, Seoul, Korea
GTZ Office Bangkok, 193/63 Lake Ratchada Bldg., 16th Floor, New Ratchadapisek Road, Bangkok 10110, Thailand
Institute of Experimental Haematology and Transfusion Medicine, University of Bonn, 53105 Bonn, Germany
corresponding author email
The electronic version of this article is the complete one and can be found online at:
3 April 2008
6 February 2009
6 February 2009
© 2009 Rost et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
), which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited.