HW 4 - BioMi 3210 Name: Net ID: Homework questions for:...

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BioMi 3210 Name: Net ID: Homework questions for: P.D. Cani and N.M. Delzenne. The gut microbiome as therapeutic target Pharmacology and Therapeutics, In Press (2011). Question 1. These authors emphasize the role of LPS and its receptors, TLR4/CD14, in metabolic inflammation. They mention that TLR4/CD14 is necessary for inflammation, citing it part that mice lacking this receptor do not develop inflammation either with a high fat diet or with LPS infusion. You have learned of another scenario that leads to inflammation, the loss of TLR5. Here is another observation: mice that lack both TLR4/CD14 and TLR5 develop inflammation and insulin resistance. Propose a mechanism that explains how mice lacking both TLR4/CD14 and TLR5 become insulin resistant. (what microbial compounds, where do they travel, etc). What experiments might you perform to test your idea? What outcomes of the experiment would support or not support your idea? (Again, we’re looking for logic, since all this is speculative – you’re at the edge of the scientific knowledge here). Things to consider:
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HW 4 - BioMi 3210 Name: Net ID: Homework questions for:...

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