(b)As in part (a), lactone formation is possible only when the hydroxyl and carboxyl groupsare cis.Although the most stable conformation of cis-3-hydroxycyclohexanecarboxylic acid has bothsubstituents equatorial and is unable to close to a lactone, the diaxial orientation is accessibleand is capable of lactone formation.Neither conformation of trans-3-hydroxycyclohexanecarboxylic acid has the substituentsclose enough to each other to form an unstrained lactone.19.25(a)The most stable conformation of formic acid is the one that has both hydrogens anti.A plausible explanation is that the syn conformation is destabilized by lone-pair repulsions.(b)A dipole moment of zero can mean that the molecule has a center of symmetry. One structure
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