Dolbier HW Solutions 456

Dolbier HW Solutions 456 - 550 CARBOXYLIC ACID DERIVATIVES:...

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Steps 4 and 5: Proton transfers to give an amide 20.24 Ketones may be prepared by the reaction of nitriles with Grignard reagents. Nucleophilic addition of a Grignard reagent to a nitrile produces an imine. The imine is not normally isolated, however, but is hydrolyzed to the corresponding ketone. Ethyl phenyl ketone may be prepared by the reaction of propanenitrile with a phenyl Grignard reagent such as phenylmagnesium bromide, followed by hydrolysis of the imine. 20.25 ( a ) The halogen that is attached to the carbonyl group is identi f ed in the name as a separate word following the name of the acyl group. ( b )T r i F uoroacetic anhydride is the anhydride of tri F uoroacetic acid. Notice that it contains six F uorines. ( c ) This compound is the cyclic anhydride of cis -1,2-cyclopropanedicarboxylic acid.
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This note was uploaded on 09/30/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.

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