Steps 4 and 5: Proton transfers to give an amide20.24Ketones may be prepared by the reaction of nitriles with Grignard reagents. Nucleophilic additionof a Grignard reagent to a nitrile produces an imine. The imine is not normally isolated, however,but is hydrolyzed to the corresponding ketone. Ethyl phenyl ketone may be prepared by the reactionof propanenitrile with a phenyl Grignard reagent such as phenylmagnesium bromide, followed byhydrolysis of the imine.20.25(a)The halogen that is attached to the carbonyl group is identifed in the name as a separate wordfollowing the name of the acyl group.(b)TriFuoroacetic anhydride is the anhydride of triFuoroacetic acid. Notice that it contains sixFuorines.(c)This compound is the cyclic anhydride of cis-1,2-cyclopropanedicarboxylic acid.
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This note was uploaded on 09/30/2011 for the course CHM 2210 taught by Professor Reynolds during the Fall '01 term at University of Florida.